Nuclear Overhauser Enhancement (noe) Mediated Chemical Exchange Saturation Transfer (cest) Imaging at 7 Tesla in Glioblastoma Patients
نویسندگان
چکیده
3745 NUCLEAR OVERHAUSER ENHANCEMENT (NOE) MEDIATED CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING AT 7 TESLA IN GLIOBLASTOMA PATIENTS Daniel Paech, Jan Eric Meissner, Johannes Windschuh, Benedikt Wiestler, Jan Oliver Neumann, Heinz Peter Schlemmer, Wolfgang Wick, Armin Nagel, Marc Ladd, Martin Bendszus, Peter Bachert, Moritz Zaiss, and Alexander Radbruch Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, BW, Germany, Neurooncologic Imaging, Department of Radiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, BW, Germany, Department of Medical Physics in Radiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, BW, Germany, Department of Neurooncology, University of Heidelberg Medical Center, Heidelberg, BW, Germany, Department of Neurosurgery, University of Heidelberg Medical Center, Heidelberg, BW, Germany, Department of Radiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, BW, Germany
منابع مشابه
Nuclear Overhauser Enhancement Mediated Chemical Exchange Saturation Transfer Imaging at 7 Tesla in Glioblastoma Patients
BACKGROUND AND PURPOSE Nuclear Overhauser Enhancement (NOE) mediated chemical exchange saturation transfer (CEST) is a novel magnetic resonance imaging (MRI) technique on the basis of saturation transfer between exchanging protons of tissue proteins and bulk water. The purpose of this study was to evaluate and compare the information provided by three dimensional NOE mediated CEST at 7 Tesla (7...
متن کاملNuclear Overhauser Enhancement Imaging of Glioblastoma at 7 Tesla: Region Specific Correlation with Apparent Diffusion Coefficient and Histology
OBJECTIVE To explore the correlation between Nuclear Overhauser Enhancement (NOE)-mediated signals and tumor cellularity in glioblastoma utilizing the apparent diffusion coefficient (ADC) and cell density from histologic specimens. NOE is one type of chemical exchange saturation transfer (CEST) that originates from mobile macromolecules such as proteins and might be associated with tumor cellul...
متن کاملImaging amide proton transfer and nuclear overhauser enhancement using chemical exchange rotation transfer (CERT).
PURPOSE This study investigates amide proton transfer (APT) and nuclear overhauser enhancement (NOE) in phantoms and 9L tumors in rat brains at 9.4 Tesla, using a recently developed method that can isolate different contributions to exchange. METHODS Chemical exchange rotation transfer (CERT) was used to quantify APT and NOEs through subtraction of signals acquired at two irradiation flip ang...
متن کاملInverse Z-spectrum analysis for clean NOE and amide CEST-MRI – application to human glioma
Inverse Z-spectrum analysis for clean NOE and amide CEST-MRI – application to human glioma Moritz Zaiss, Johannes Windschuh, Jan-Eric Meissner, Daniel Paech, Alexander Radbruch, and Peter Bachert Dept. Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Dept. of Neuroradiology, University of Heidelberg, Heidelberg, Germany, Section Neuro–oncologic Imaging, G...
متن کاملComparison of pulsed three‐dimensional CEST acquisition schemes at 7 tesla: steady state versus pseudosteady state
PURPOSE To compare two pulsed, volumetric chemical exchange saturation transfer (CEST) acquisition schemes: steady state (SS) and pseudosteady state (PS) for the same brain coverage, spatial/spectral resolution and scan time. METHODS Both schemes were optimized for maximum sensitivity to amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) effects through Bloch-McConnell simul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013